Article
Identification and characterization of a novel transcriptional activation domain in the CREB-binding protein.
The Journal of biological chemistry - 26 Jul 1996
Bisotto S, Minorgan S, Rehfuss R P
Abstract excerpt
The CREB-binding protein (CBP) plays a central role in the regulation of gene expression by several different second messenger pathways including serum growth factors, cAMP and phorbol esters. CBP specifically binds to the phosphorylated forms of CREB and c-Jun and is thought to activate transcri...
Topics
- Activating Transcription Factor 1
- Binding Sites
- CREB-Binding Protein
- Cyclic AMP Response Element-Binding Protein
- DNA Mutational Analysis
- DNA-Binding Proteins
- Mutation
- Nuclear Proteins
- Protein Binding
- Sequence Deletion
- Structure-Activity Relationship
- Trans-Activators
- Transcription Factor TFIIB
- Transcription Factors
- Transcription, Genetic