Article
The helix-turn-helix motif as an ultrafast independently folding domain: the pathway of folding of Engrailed homeodomain.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007
Religa Tomasz L, Johnson Christopher M, Vu Dung M, Brewer Scott H, Dyer R Brian, Fersht Alan R
Abstract excerpt
Helices 2 and 3 of Engrailed homeodomain (EnHD) form a helix-turn-helix (HTH) motif. This common motif is believed not to fold independently, which is the characteristic feature of a motif rather than a domain. But we found that the EnHD HTH motif is monomeric and folded in solution, having essentially the same structure as in full-length protein. It had a sigmoidal thermal denaturation transition. Both native...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.