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Article

Gradual disordering of the native state on a slow two-state folding protein monitored by single-molecule fluorescence spectroscopy and NMR.

The journal of physical chemistry. B - 24 Oct 2013

Campos Luis A, Sadqi Mourad, Liu Jianwei, Wang Xiang, English Douglas S, Muñoz Victor

Abstract excerpt

Theory predicts that folding free energy landscapes are intrinsically malleable and as such are expected to respond to perturbations in topographically complex ways. Structural changes upon perturbation have been observed experimentally for unfolded ensembles, folding transition states, and fast downhill folding proteins. However, the native state of proteins that fold in a two-state fashion is conventionally...

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PMID: 23796244
DOI: 10.1021/jp403051k

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