Article
High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein.
Proceedings of the National Academy of Sciences of the United States of America - 24 May 2005
Chiu Thang K, Kubelka Jan, Herbst-Irmer Regine, Eaton William A, Hofrichter James, Davies David R
Abstract excerpt
The 35-residue subdomain of the villin headpiece (HP35) is a small ultrafast folding protein that is being intensely studied by experiments, theory, and simulations. We have solved the x-ray structures of HP35 and its fastest folding mutant [K24 norleucine (nL)] to atomic resolution and compared their experimentally measured folding kinetics by using laser temperature jump. The structures, which are in different...
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