Article
Solution structure of a protein denatured state and folding intermediate.
Nature - 13 Oct 2005
Religa T L, Markson J S, Mayor U, Freund S M V, Fersht A R
Abstract excerpt
The most controversial area in protein folding concerns its earliest stages. Questions such as whether there are genuine folding intermediates, and whether the events at the earliest stages are just rearrangements of the denatured state or progress from populated transition states, remain unresolved. The problem is that there is a lack of experimental high-resolution structural information about early folding...
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