Article
The denatured state of Engrailed Homeodomain under denaturing and native conditions.
Journal of molecular biology - 7 Nov 2003
Mayor Ugo, Grossmann J Günter, Foster Nicholas W, Freund Stefan M V, Fersht Alan R
Abstract excerpt
Protein folding starts from the elusive form of the denatured state that is present under conditions that favour the native state. We have studied the denatured state of Engrailed Homeodomain (En-HD) under mildly and strongly denaturing conditions at the level of individual residues by NMR and more globally by conventional spectroscopy and solution X-ray scattering. We have compared these states with a...
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