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Article

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

De Ferrari Giancarlo V, Papassotiropoulos Andreas, Biechele Travis, Wavrant De-Vrieze Fabienne, Avila Miguel E, Major Michael B, Myers Amanda, Sáez Katia, Henríquez Juan P, Zhao Alice, Wollmer M Axel, Nitsch Roger M, Hock Christoph, Morris Chris M, Hardy John, Moon Randall T

Abstract excerpt

Genome-wide linkage studies have defined a broad susceptibility region for late-onset Alzheimer's disease on chromosome 12, which contains the Low-Density Lipoprotein Receptor-Related Protein 6 (LRP6) gene, a coreceptor for Wnt signaling. Here, we report the association between common LRP6 varian...

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Identifiers

PMID: 17517621
DOI: 10.1073/pnas.0603523104
PMCID: PMC1890512

Genes

LRP6
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17517621-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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