Article

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during ageing and in Alzheimer’s disease

2022-04-08

Abstract excerpt

Synapse loss strongly correlates with cognitive decline in Alzheimer’s Disease (AD), but the underlying mechanisms are poorly understood. Studies suggest that deficient Wnt signalling, a pathway required for neuronal connectivity, contributes to synapse dysfunction and loss in AD. Consistent with this idea, a variant of Lrp6, (Lrp6-val) , which confers reduced Wnt signalling, has been linked to late onset AD. How...

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Literature Corpus work: db7b553a-befd-5858-8be7-e40b7c55d357
DOI: 10.1101/2022.04.06.487208

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