Article
A common variant in low-density lipoprotein receptor-related protein 6 gene (LRP6) is associated with LDL-cholesterol.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2009
Tomaszewski Maciej, Charchar Fadi J, Barnes Timothy, Gawron-Kiszka Magdalena, Sedkowska Agnieszka, Podolecka Ewa, Kowalczyk Jacek, Rathbone Wendy, Kalarus Zbigniew, Grzeszczak Wladyslaw, Goodall Alison H, Samani Nilesh J, Zukowska-Szczechowska Ewa
Abstract excerpt
OBJECTIVE: A rare mutation in low-density lipoprotein receptor-related protein 6 gene (LRP6) was identified as the primary molecular defect underlying monogenic form of coronary artery disease. We hypothesized that common variants in LRP6 could predispose subjects to elevated LDL-cholesterol (LDL-C). METHODS AND RESULTS: Twelve common (minor allele frequency > or =0.1) single nucleotide polymorphisms in LRP6 were...
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