Article
LRP6 mutation in a family with early coronary disease and metabolic risk factors.
Science (New York, N.Y.) - 2 Mar 2007
Mani Arya, Radhakrishnan Jayaram, Wang He, Mani Alaleh, Mani Mohammad-Ali, Nelson-Williams Carol, Carew Khary S, Mane Shrikant, Najmabadi Hossein, Wu Dan, Lifton Richard P
Abstract excerpt
Coronary artery disease (CAD) is the leading cause of death worldwide and is commonly caused by a constellation of risk factors called the metabolic syndrome. We characterized a family with autosomal dominant early CAD, features of the metabolic syndrome (hyperlipidemia, hypertension, and diabetes), and osteoporosis. These traits showed genetic linkage to a short segment of chromosome 12p, in which we identified...
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