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Article

Sequence variants of interleukin 6 (IL-6) are significantly associated with a decreased risk of late-onset Alzheimer's disease.

Journal of neuroinflammation - 24 Jan 2012

Chen Shih-Yuan, Chen Ta-Fu, Lai Liang-Chuan, Chen Jen-Hau, Sun Yu, Wen Li-Li, Yip Ping-Keung, Chu Yi-Min, Chen Yen-Ching

Abstract excerpt

BACKGROUND: Interleukin 6 (IL-6) has been related to beta-amyloid aggregation and the appearance of hyperphosphorylated tau in Alzheimer's disease (AD) brain. However, previous studies relating IL-6 genetic polymorphisms to AD included few and unrepresentative single nucleotide polymorphisms (SNPs) and the results were inconsistent. METHODS: This is a case-control study. A total of 266 patients with AD, aged≧65,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22272811
DOI: 10.1186/1742-2094-9-21
PMCID: PMC3315433

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