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Article

Functional analysis LRP6 novel mutations in patients with coronary artery disease.

PloS one - 1 Jan 2014

Xu Yujun, Gong Wei, Peng Jia, Wang Haoran, Huang Jin, Ding Hu, Wang Dao Wen

Abstract excerpt

BACKGROUND: Genetic architecture of coronary artery disease (CAD) is still to be defined. Since low density lipoprotein receptor-related protein 6 (LRP6) gene play critical roles in Wnt signal transduction which are important for vascular development and endodermis specification, we therefore resequenced it to search for mutations in CAD patients. METHODS: We systemically sequenced all the exons and promoter...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Low Density Lipoprotein Receptor-Related Protein-6

Share to Mutation, Missense

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Source

Open in PubMed Open full text

Identifiers

PMID: 24427284
DOI: 10.1371/journal.pone.0084345
PMCID: PMC3888387

Genes

LRP6
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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