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Article

Differential effects of paramyotonia congenita mutations F1473S and F1705I on sodium channel gating.

Channels (Austin, Tex.) - 1 Jan 2000

Groome James R, Larsen Matthew F, Coonts Allyson

Abstract excerpt

We investigated effects of paramyotonia congenita mutations F1473S and F1705I on gating of skeletal muscle Na+ channels. We used on-cell recordings from Xenopus oocytes to compare fast inactivation and deactivation in wild-type and mutant channels. Then, we used gating current recordings to determine how these actions of PC mutants might be reflected in their effects on charge movement and its immobilization....

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Identifiers

PMID: 18690054
DOI: 10.4161/chan.2.1.6051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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