Article
CAPN10 mRNA splicing and decay is not affected by a SNP associated with susceptibility to type 2 diabetes.
Biochemical and biophysical research communications - 6 Jul 2007
López-Orduña Eduardo, García-Mena Jaime, García-Macedo Rebeca, Stumvoll Michael, Cruz Miguel
Abstract excerpt
The mRNA concentration of CAPN10, a T2D susceptibility gene was measured in white blood cells of T2D and healthy subjects, as well as the transcript half-life in two SNP-43 genotyped human cell lines, to evaluate a possible relationship between this SNP-43 and the transcript half-life. T2D patients with the SNP-43 G-allele had 4.6-fold more CAPN10 transcripts compared to subjects with the A-allele. The mRNA...
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