Article
Reduced skeletal muscle calpain-10 transcript level is due to a cumulative decrease in major isoforms.
Molecular genetics and metabolism - 1 May 2001
Yang X, Pratley R E, Baier L J, Horikawa Y, Bell G I, Bogardus C, Permana P A
Abstract excerpt
The DNA polymorphism SNP-43 in the calpain-10 gene is associated with insulin resistance and reduced skeletal muscle transcript in Pima Indians. Alternative splicing generates transcript isoforms calpain-10a to -10h. We determined the contribution of calpain-10 mRNA isoforms to the decreased tota...
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