Article
Genetic and nongenetic regulation of CAPN10 mRNA expression in skeletal muscle.
Diabetes - 1 Oct 2005
Carlsson Emma, Poulsen Pernille, Storgaard Heidi, Almgren Peter, Ling Charlotte, Jensen Christine Bjørn, Madsbad Sten, Groop Leif, Vaag Allan, Ridderstråle Martin
Abstract excerpt
The gene encoding calpain-10 (CAPN10) has been identified as a candidate gene for type 2 diabetes. Our aim was to study the impact of genetic (heritability and polymorphisms) and nongenetic (insulin, free fatty acids, and age) factors on CAPN10 mRNA expression in skeletal muscle using two different study designs. Muscle biopsies were obtained before and after hyperinsulinemic-euglycemic clamps from 166 young and...
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