Article
Variation in the calpain-10 gene affects blood glucose levels in the British population.
Diabetes - 1 Jan 2002
Lynn Stephen, Evans Julie C, White Christopher, Frayling Timothy M, Hattersley Andrew T, Turnbull Doug M, Horikawa Yukio, Cox Nancy J, Bell Graeme I, Walker Mark
Abstract excerpt
Variation in the calpain-10 gene (CAPN10) has been shown to be associated with type 2 diabetes in Mexican-Americans and in at least three Northern European populations. Studies in nondiabetic Pima Indians showed that one of the at-risk DNA polymorphisms, single-nucleotide polymorphism (SNP)-43, in CAPN10 was associated with insulin resistance, and individuals with the G/G-genotype had significantly higher fasting...
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