Article
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.
The Journal of clinical investigation - 1 Oct 2000
Baier L J, Permana P A, Yang X, Pratley R E, Hanson R L, Shen G Q, Mott D, Knowler W C, Cox N J, Horikawa Y, Oda N, Bell G I, Bogardus C
Abstract excerpt
Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently found to be associated with a common G-->A polymorphism (UCSNP-43) within the CAPN10 gene. The at-risk genotype was homozygous for the UCSNP-43 G allele. In the present study among Pima Indians, the UCSNP-43 G/G genotype was...
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