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Article

Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutation.

Haematologica - 1 Jun 2008

Navarro Silvia, Medina Pilar, Mira Yolanda, Estellés Amparo, Villa Piedad, Ferrando Fernando, Vayá Amparo, Bertina Rogier M, España Francisco

Abstract excerpt

BACKGROUND: Haplotypes A1 and A3 in the endothelial protein C receptor (EPCR) gene are tagged by 4678G/C and 4600A/G respectively. We assessed whether these haplotypes modify the risk of venous thromboembolism in carriers of the prothrombin 20210A allele. DESIGN AND METHODS: We genotyped 4678G/C and 4600A/G in 246 20210A carriers: 84 venous thromboembolism propositi and 162 relatives (13 symptomatic), and in 140...

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PMID: 18403391
DOI: 10.3324/haematol.12448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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