Article
Analysis of keratin polypeptides 8 and 19 variants in inflammatory bowel disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jul 2007
Tao Guo-Zhong, Strnad Pavel, Zhou Qin, Kamal Ahmad, Zhang Leilei, Madani Nahid D, Kugathasan Subra, Brant Steven R, Cho Judy H, Omary M Bishr, Duerr Richard H
Abstract excerpt
BACKGROUND/AIMS: Keratin-8 (KRT8)-null mice develop spontaneous colitis and predisposition to liver injury. Human studies show that some KRT8 variants predispose to end-stage liver disease and progression and suggest that such variants might associate with UC or CD. We asked whether mutations in KRT8 or KRT19, the major intestinal keratins, are associated with UC/CD. METHODS: Exonic regions of the KRT8/KRT19...
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