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Article

Intestinal cell barrier function in vitro is severely compromised by keratin 8 and 18 mutations identified in patients with inflammatory bowel disease.

PloS one - 1 Jan 2014

Zupancic Tina, Stojan Jure, Lane Ellen Birgitte, Komel Radovan, Bedina-Zavec Apolonija, Liovic Mirjana

Abstract excerpt

Keratin 8 and 18 (K8/K18) mutations have been implicated in the aetiology of certain pathogenic processes of the liver and pancreas. While some K8 mutations (K8 G62C, K8 K464N) are also presumed susceptibility factors for inflammatory bowel disease (IBD), the only K18 mutation (K18 S230T) discove...

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Identifiers

PMID: 24915158
DOI: 10.1371/journal.pone.0099398
PMCID: PMC4051775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24915158-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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