Article
Human keratin 8 mutations that disturb filament assembly observed in inflammatory bowel disease patients.
Journal of cell science - 15 Apr 2004
Owens D W, Wilson N J, Hill A J M, Rugg E L, Porter R M, Hutcheson A M, Quinlan R A, van Heel D, Parkes M, Jewell D P, Campbell S S, Ghosh S, Satsangi J, Lane E B
Abstract excerpt
We have identified miss-sense mutations in keratin 8 in a subset of patients with inflammatory bowel disease (Crohn disease and ulcerative colitis). Inflammatory bowel diseases are a group of disorders that are polygenic in origin and involve intestinal epithelial breakdown. We investigated the possibility that these keratin mutations might contribute to the course of the disease by adversely affecting the...
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