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Article

Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 May 2007

Chen Jinyun, Li Donghui, Wei Chongjuan, Sen Subrata, Killary Ann M, Amos Christopher I, Evans Douglas B, Abbruzzese James L, Frazier Marsha L

Abstract excerpt

PURPOSE: Aurora-A and p16 play a major role in cell cycle checkpoint regulation. Both of them are important in the maintenance of centrosome duplication. Therefore, we hypothesized that polymorphisms in the two genes may interact or work together to influence the finely tuned mechanisms of cell cycle regulation that these proteins regulate. The purpose of this study was to investigate the association of the...

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Identifiers

PMID: 17505013
DOI: 10.1158/1078-0432.CCR-06-2319
PMCID: PMC2365501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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