Article
Functional single nucleotide polymorphisms within the cyclin-dependent kinase inhibitor 2A/2B region affect pancreatic cancer risk.
Oncotarget - 30 Aug 2016
Campa Daniele, Pastore Manuela, Gentiluomo Manuel, Talar-Wojnarowska Renata, Kupcinskas Juozas, Malecka-Panas Ewa, Neoptolemos John P, Niesen Willem, Vodicka Pavel, Delle Fave Gianfranco, Bueno-de-Mesquita H Bas, Gazouli Maria, Pacetti Paola, Di Leo Milena, Ito Hidemi, Klüter Harald, Soucek Pavel, Corbo Vincenzo, Yamao Kenji, Hosono Satoyo, Kaaks Rudolf, Vashist Yogesh, Gioffreda Domenica, Strobel Oliver, Shimizu Yasuhiro, Dijk Frederike, Andriulli Angelo, Ivanauskas Audrius, Bugert Peter, Tavano Francesca, Vodickova Ludmila, Zambon Carlo Federico, Lovecek Martin, Landi Stefano, Key Timothy J, Boggi Ugo, Pezzilli Raffaele, Jamroziak Krzysztof, Mohelnikova-Duchonova Beatrice, Mambrini Andrea, Bambi Franco, Busch Olivier, Pazienza Valerio, Valente Roberto, Theodoropoulos George E, Hackert Thilo, Capurso Gabriele, Cavestro Giulia Martina, Pasquali Claudio, Basso Daniela, Sperti Cosimo, Matsuo Keitaro, Büchler Markus, Khaw Kay-Tee, Izbicki Jakob, Costello Eithne, Katzke Verena, Michalski Christoph, Stepien Anna, Rizzato Cosmeri, Canzian Federico
Abstract excerpt
The CDKN2A (p16) gene plays a key role in pancreatic cancer etiology. It is one of the most commonly somatically mutated genes in pancreatic cancer, rare germline mutations have been found to be associated with increased risk of developing familiar pancreatic cancer and CDKN2A promoter hyper-methylation has been suggested to play a critical role both in pancreatic cancer onset and prognosis. In addition several...
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