Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.

Tumori - 1 Jan 2000

Ruiz-Tovar Jaime, Fernandez-Contreras Maria Encarnación, Martín-Perez Elena, Gamallo Carlos

Abstract excerpt

BACKGROUND: Thymidylate synthase and hypoxia inducible factor-1α play a central role in the control of tumor progression. In the present study, we investigated the effect of three DNA polymorphisms within the thymidylate synthase gene and two within hypoxia inducible factor-1α on the prognosis of pancreatic cancer. PATIENTS AND METHODS: A retrospective study was performed in 59 patients diagnosed with invasive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease-Free Survival

Share to DNA, Neoplasm

Share to Hypoxia-Inducible Factor 1, alpha Subunit

Share to Minisatellite Repeats

Share to Pancreatic Neoplasms

Share to Thymidylate Synthase

Source

Identifiers

PMID: 22825513
DOI: 10.1177/030089161209800314

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of thymidylate synthase and hypoxia inducible factor-1alpha DNA polymorphisms with pancreatic cancer.PMID 22825513Read ↗

Polymorphisms in the hypoxia-inducible factor-1α gene confer susceptibility to pancreatic cancer.Semantic proximity Read ↗

Associations between gene polymorphisms of thymidylate synthase with its protein expression and chemosensitivity to 5-fluorouracil in pancreatic carcinoma cells.Semantic proximity Read ↗

Association between genetic polymorphisms in long non-coding RNAs and pancreatic cancer risk.Semantic proximity Read ↗

Genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase and risk of pancreatic cancer.Semantic proximity Read ↗

Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes.Semantic proximity Read ↗

Assessment of Telomere Length and Molecular Characterization of TERT Gene Promoter in Periampullary CarcinomasSemantic proximity Read ↗

His595Tyr polymorphism in the methionine synthase reductase (MTRR) gene is associated with pancreatic cancer risk.Semantic proximity Read ↗

Effects of base excision repair gene polymorphisms on pancreatic cancer survival.Semantic proximity Read ↗

Telomere length assessment and molecular characterization of TERT gene promoter in periampullary carcinomas.Semantic proximity Read ↗

Pharmacogenetic study in rectal cancer patients treated with preoperative chemoradiotherapy: polymorphisms in thymidylate synthase, epidermal growth factor receptor, GSTP1, and DNA repair genes.Semantic proximity Read ↗

HIF-1α P582S and A588T polymorphisms and digestive system cancer risk-a meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms in the microRNA binding-sites of the thymidylate synthase gene predict risk and survival in gastric cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.