A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

doi:10.1086/509517

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Article

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses.

American journal of human genetics - 1 Dec 2006

Weedon Michael N, Clark Vanessa J, Qian Yudong, Ben-Shlomo Yoav, Timpson Nicholas, Ebrahim Shah, Lawlor Debbie A, Pembrey Marcus E, Ring Susan, Wilkin Terry J, Voss Linda D, Jeffery Alison N, Metcalf Brad, Ferrucci Luigi, Corsi Anna Maria, Murray Anna, Melzer David, Knight Bridget, Shields Bev, Smith George Davey, Hattersley Andrew T, Di Rienzo Anna, Frayling Tim M

Abstract excerpt

Fasting glucose is associated with future risk of type 2 diabetes and ischemic heart disease and is tightly regulated despite considerable variation in quantity, type, and timing of food intake. In pregnancy, maternal fasting glucose concentration is an important determinant of offspring birth weight. The key determinant of fasting glucose is the enzyme glucokinase (GCK). Rare mutations of GCK cause fasting...

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PMID: 17186458
DOI: 10.1086/509517
PMCID: PMC1698701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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