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Article

Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.

Leukemia research - 1 Oct 2009

Hohaus Stefan, Giachelia Manuela, Massini Giuseppina, Vannata Barbara, Criscuolo Marianna, Martini Maurizio, D'Alo' Francesco, Voso Maria Teresa, Larocca Luigi Maria, Leone Giuseppe

Abstract excerpt

We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the...

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Identifiers

PMID: 19201467
DOI: 10.1016/j.leukres.2009.01.009

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