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Article

Cyclooxygenase polymorphisms and risk of cardiovascular events: the Atherosclerosis Risk in Communities (ARIC) study.

Clinical pharmacology and therapeutics - 1 Jan 2008

Lee C R, North K E, Bray M S, Couper D J, Heiss G, Zeldin D C

Abstract excerpt

Cyclooxygenase-derived prostaglandins modulate cardiovascular disease risk. We genotyped 2212 Atherosclerosis Risk in Communities study participants (1,023 incident coronary heart disease (CHD) cases; 270 incident ischemic stroke cases; 919 non-cases) with available DNA for polymorphisms in PTGS1 and PTGS2. Using a case-cohort design, associations between genotype and CHD or stroke risk were evaluated using...

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Identifiers

PMID: 17495879
DOI: 10.1038/sj.clpt.6100221
PMCID: PMC2244790

Genes

PTGS2
PTGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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