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Article

Thermal unfolding of human BRCA1 BRCT-domain variants.

Biochimica et biophysica acta - 1 Jun 2007

Nikolopoulos George, Pyrpassopoulos Serapion, Thanassoulas Angelos, Klimentzou Persefoni, Zikos Christos, Vlassi Metaxia, Vorgias Constantinos E, Yannoukakos Drakoulis, Nounesis George

Abstract excerpt

Missense mutations at the BRCT domain of human BRCA1 protein have been associated with an elevated risk for hereditary breast/ovarian cancer. They have been shown to affect the binding site and they have also been proposed to affect domain stability, severely hampering the protein's tumor suppressor function. In order to assess the impact of various such mutations upon the stability and the function of the BRCT...

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Source

Identifiers

PMID: 17493881
DOI: 10.1016/j.bbapap.2007.03.018

Genes

BRCA1
BACH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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