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Article

Thermal denaturation of the BRCT tandem repeat region of human tumour suppressor gene product BRCA1.

Biophysical chemistry - 1 Apr 2005

Pyrpassopoulos Serapion, Ladopoulou Angela, Vlassi Metaxia, Papanikolau Yannis, Vorgias Constantinos E, Yannoukakos Drakoulis, Nounesis George

Abstract excerpt

Reduced stability of the tandem BRCT domains of human BReast CAncer 1 (BRCA1) due to missense mutations may be critical for loss of function in DNA repair and damage-induced checkpoint control. In the present thermal denaturation study of the BRCA1 BRCT region, high-precision differential scanning calorimetry (DSC) and circular dichroism (CD) spectroscopy provide evidence for the existence of a denatured state...

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Share to BRCA1 Protein
Share to Calorimetry, Differential Scanning

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15792855
DOI: 10.1016/j.bpc.2004.09.014

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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