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Article

Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.

Journal of molecular biology - 12 Jul 2002

Ekblad C M S, Wilkinson H R, Schymkowitz J W H, Rousseau F, Freund S M V, Itzhaki L S

Abstract excerpt

The breast cancer susceptibility gene product BRCA1 is a tumour suppressor but the biochemical and biological functions that underlie its role in carcinogenesis remain to be determined. Here, we characterise the solution properties of the highly conserved C terminus of BRCA1, consisting of a tand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12096901
DOI: 10.1016/s0022-2836(02)00478-3

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12096901-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.PMID 12096901Read ↗

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Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.Semantic proximity Read ↗

Structure-based assessment of missense mutations in human BRCA1: implications for breast and ovarian cancer predisposition.Semantic proximity Read ↗

[Mapping of BRCT1 domain of BRCA1 with chromatin unfolding activity].Semantic proximity Read ↗

Mutations in the BRCT domain confer temperature sensitivity to BRCA1 in transcription activation.Semantic proximity Read ↗

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