Article
Ancestral haplotype-based association mapping with generalized linear mixed models accounting for stratification.
Bioinformatics (Oxford, England) - 1 Oct 2012
Zhang Z, Guillaume F, Sartelet A, Charlier C, Georges M, Farnir F, Druet T
Abstract excerpt
MOTIVATION: In many situations, genome-wide association studies are performed in populations presenting stratification. Mixed models including a kinship matrix accounting for genetic relatedness among individuals have been shown to correct for population and/or family structure. Here we extend this methodology to generalized linear mixed models which properly model data under various distributions. In addition we...
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