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Gene-based analysis of bi-variate survival traits via functional regressions with applications to eye diseases.

Genetic epidemiology - 1 Jul 2021

Zhang Bingsong, Chiu Chi-Yang, Yuan Fang, Sang Tian, Cook Richard J, Wilson Alexander F, Bailey-Wilson Joan E, Chew Emily Y, Xiong Momiao, Fan Ruzong

Abstract excerpt

Genetic studies of two related survival outcomes of a pleiotropic gene are commonly encountered but statistical models to analyze them are rarely developed. To analyze sequencing data, we propose mixed effect Cox proportional hazard models by functional regressions to perform gene-based joint association analysis of two survival traits motivated by our ongoing real studies. These models extend fixed effect Cox...

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PMID: 33645812
DOI: 10.1002/gepi.22381

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