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Article

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.

Immunology - 1 Sept 2007

Fan Hongkuan, Williams David L, Zingarelli Basilia, Breuel Kevin F, Teti Giuseppe, Tempel George E, Spicher Karsten, Boulay Guylain, Birnbaumer Lutz, Halushka Perry V, Cook James A

Abstract excerpt

Heterotrimeric G(i) proteins play a role in signalling activated by lipopolysaccharide (LPS), Staphylococcus aureus (SA) and group B streptococci (GBS), leading to production of inflammatory mediators. We hypothesized that genetic deletion of G(i) proteins would alter cytokine and chemokine production induced by LPS, SA and GBS stimulation. LPS-induced, heat-killed SA-induced and heat-killed GBS-induced cytokine...

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Identifiers

PMID: 17484771
DOI: 10.1111/j.1365-2567.2007.02619.x
PMCID: PMC2265979

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MIP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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