Article
Glucan phosphate attenuates myocardial HMGB1 translocation in severe sepsis through inhibiting NF-κB activation.
American journal of physiology. Heart and circulatory physiology - 1 Sept 2011
Ha Tuanzhu, Xia Yeling, Liu Xiang, Lu Chen, Liu Li, Kelley Jim, Kalbfleisch John, Kao Race L, Williams David L, Li Chuanfu
Abstract excerpt
Myocardial dysfunction is a major consequence of septic shock and contributes to the high mortality of sepsis. High-mobility group box 1 (HMGB1) serves as a late mediator of lethality in sepsis. We have reported that glucan phosphate (GP) attenuates cardiac dysfunction and increases survival in cecal ligation and puncture (CLP)-induced septic mice. In the present study, we examined the effect of GP on HMGB1...
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