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Article

COMT val158met predicts reward responsiveness in humans.

Genes, brain, and behavior - 1 Nov 2012

Lancaster T M, Linden D E, Heerey E A

Abstract excerpt

A functional variant of the catechol-O-methyltransferase (COMT) gene [val158met (rs4680)] is frequently implicated in decision-making and higher cognitive functions. It may achieve its effects by modulating dopamine-related decision-making and reward-guided behaviour. Here we demonstrate that individuals with the met/met polymorphism have greater responsiveness to reward than carriers of the val allele and that...

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Source

Identifiers

PMID: 22900954
DOI: 10.1111/j.1601-183X.2012.00838.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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COMT val158met predicts reward responsiveness in humans.PMID 22900954Read ↗

Replication study implicates COMT val158met polymorphism as a modulator of probabilistic reward learning.Semantic proximity Read ↗

COMT Val(158) Met genotype is associated with reward learning: a replication study and meta-analysis.Semantic proximity Read ↗

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Catechol-O-methyltransferase val158met genotype influences neural processing of reward anticipation.Semantic proximity Read ↗

DAT1 polymorphism is associated with risk taking in the Balloon Analogue Risk Task (BART).Semantic proximity Read ↗

Warriors versus worriers: the role of COMT gene variants.Semantic proximity Read ↗

COMT Val158Met Genotype Determines the Direction of Cognitive Effects Produced by Catechol-O-Methyltransferase InhibitionSemantic proximity Read ↗

The relationship between risk-taking propensity and the COMT Val(158)Met polymorphism among early adolescents as a function of sex.Semantic proximity Read ↗

Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis.Semantic proximity Read ↗

Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex.Semantic proximity Read ↗

Polygenic Contributions to Performance on the Balloon Analogue Risk TaskSemantic proximity Read ↗

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