Article
An IPTG Inducible Conditional Expression System for Mycobacteria.
PloS one - 1 Jan 2015
Ravishankar Sudha, Ambady Anisha, Ramu Haripriya, Mudugal Naina Vinay, Tunduguru Ragadeepthi, Anbarasu Anand, Sharma Umender K, Sambandamurthy Vasan K, Ramaiah Sudha
Abstract excerpt
Conditional expression strains serve as a valuable tool to study the essentiality and to establish the vulnerability of a target under investigation in a drug discovery program. While essentiality implies an absolute requirement of a target function, vulnerability provides valuable information on the extent to which a target function needs to be depleted to achieve bacterial growth inhibition followed by cell...
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