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Article

Extracellular interactions between GluR2 and N-cadherin in spine regulation.

Neuron - 3 May 2007

Saglietti Laura, Dequidt Caroline, Kamieniarz Kinga, Rousset Marie-Claude, Valnegri Pamela, Thoumine Olivier, Beretta Francesca, Fagni Laurent, Choquet Daniel, Sala Carlo, Sheng Morgan, Passafaro Maria

Abstract excerpt

Via its extracellular N-terminal domain (NTD), the AMPA receptor subunit GluR2 promotes the formation and growth of dendritic spines in cultured hippocampal neurons. Here we show that the first N-terminal 92 amino acids of the extracellular domain are necessary and sufficient for GluR2's spine-promoting activity. Moreover, overexpression of this extracellular domain increases the frequency of miniature excitatory...

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Identifiers

PMID: 17481398
DOI: 10.1016/j.neuron.2007.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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