Article
Fibroblast growth factor receptor signaling affects development and function of dopamine neurons - inhibition results in a schizophrenia-like syndrome in transgenic mice.
Journal of neurochemistry - 1 Jun 2006
Klejbor Ilona, Myers Jason M, Hausknecht Kathy, Corso Thomas D, Gambino Angelo S, Morys Janusz, Maher Pamela A, Hard Robert, Richards Jerry, Stachowiak Ewa K, Stachowiak Michal K
Abstract excerpt
Developing and mature midbrain dopamine (DA) neurons express fibroblast growth factor (FGF) receptor-1 (FGFR1). To determine the role of FGFR1 signaling in the development of DA neurons, we generated transgenic mice expressing a dominant negative mutant [FGFR1(TK-)] from the catecholaminergic, neuron-specific tyrosine hydroxylase (TH) gene promoter. In homozygous th(tk-)/th(tk-) mice, significant reductions in...
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