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Article

Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities.

Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 2009

Samaco Rodney C, Mandel-Brehm Caleigh, Chao Hsiao-Tuan, Ward Christopher S, Fyffe-Maricich Sharyl L, Ren Jun, Hyland Keith, Thaller Christina, Maricich Stephen M, Humphreys Peter, Greer John J, Percy Alan, Glaze Daniel G, Zoghbi Huda Y, Neul Jeffrey L

Abstract excerpt

Rett syndrome (RTT) is characterized by specific motor, cognitive, and behavioral deficits. Because several of these abnormalities occur in other disease states associated with alterations in aminergic neurotransmitters, we investigated the contribution of such alterations to RTT pathogenesis. We...

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Source

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Identifiers

PMID: 20007372
DOI: 10.1073/pnas.0912257106
PMCID: PMC2799790

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007372-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Loss of MeCP2 in aminergic neurons causes cell-autonomous defects in neurotransmitter synthesis and specific behavioral abnormalities.PMID 20007372Read ↗

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