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Article

RET Is Dispensable for Maintenance of Midbrain Dopaminergic Neurons in Adult Mice

25 Oct 2006

Abstract excerpt

Glial cell-line derived neurotrophic factor (GDNF)-mediated RET tyrosine kinase signaling is implicated in the survival of several PNS and CNS neuronal populations that are important in the pathogenesis of several disorders including Parkinson's disease and drug addiction. However, it has been difficult to study these processes and the physiological importance of this pathway in adult mice because of the neonatal...

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PMID: 17065462
DOI: 10.1523/jneurosci.1876-06.2006

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