Article
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS.
Proceedings of the National Academy of Sciences of the United States of America - 8 May 2007
Sun Chaohong, Song Danying, Davis-Taber Rachel A, Barrett Leo W, Scott Victoria E, Richardson Paul L, Pereda-Lopez Ana, Uchic Marie E, Solomon Larry R, Lake Marc R, Walter Karl A, Hajduk Philip J, Olejniczak Edward T
Abstract excerpt
The pituitary adenylate cyclase-activating polypeptide (PACAP) receptor is a class II G protein-coupled receptor that contributes to many different cellular functions including neurotransmission, neuronal survival, and synaptic plasticity. The solution structure of the potent antagonist PACAP (residues 6'-38') complexed to the N-terminal extracellular (EC) domain of the human splice variant hPAC1-R-short...
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