Article
Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors.
The Journal of biological chemistry - 28 Dec 2007
Perrin Marilyn H, Grace Christy R R, Digruccio Michael R, Fischer Wolfgang H, Maji Samir K, Cantle Jeffrey P, Smith Sean, Manning Gerard, Vale Wylie W, Riek Roland
Abstract excerpt
The G-protein-coupled receptor B1 family includes corticotropin-releasing factor (CRF), growth hormone-releasing hormone, incretin, and pituitary adenylate cyclase-activating polypeptide receptors. The three-dimensional NMR structure of the first extracellular domain (ECD1) of CRF receptor 2beta (CRF-R2beta), free and complexed with astressin, comprises a Sushi domain. This domain is stabilized in part by a salt...
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