Article
New insights into alternative mechanisms of immune receptor diversification.
Advances in immunology - 1 Jan 2005
Litman Gary W, Cannon John P, Rast Jonathan P
Abstract excerpt
The clonal commitment, selection, and expansion of B and T lymphocytes expressing diversified receptors provide the underlying basis for the jawed vertebrates adaptive immune response. At the core of this process is the rearrangement and somatic modification of segmental genetic elements that encode the constituent components of immunoglobulins and T-cell antigen receptors. No evidence has been found for a...
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