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Article

Parasite-intrinsic factors can explain ordered progression of trypanosome antigenic variation

26 Apr 2007

Abstract excerpt

Pathogens often persist during infection because of antigenic variation in which they evade immunity by switching between distinct surface antigen variants. A central question is how ordered appearance of variants, an important determinant of chronicity, is achieved. Theories suggest that it results directly from a complex pattern of transition connectivity between variants or indirectly from effects such as...

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PMID: 17463092
DOI: 10.1073/pnas.0606206104

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