Transmission Stages Dominate Trypanosome Within-Host Dynamics during Chronic Infections

Abstract excerpt

Sleeping sickness is characterized by waves of the extracellular parasite Trypanosoma brucei in host blood, with infections continuing for months or years until inevitable host death. These waves reflect the dynamic conflict between the outgrowth of a succession of parasite antigenic variants and their control by the host immune system. Although a contributor to these dynamics is the density-dependent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Evolution and Genetic Dynamics
• Share to Research on Leishmaniasis Studies
• Share to Trypanosoma species research and implications