Article
The genetic influence of the nonclassical MHC molecule HLA-G on multiple sclerosis.
Human immunology - 1 May 2007
Kroner Antje, Grimm Alexander, Johannssen Kirsten, Mäurer Mathias, Wiendl Heinz
Abstract excerpt
Human leukocyte antigen (HLA)-G is a nonclassical major histocompatibility complex (MHC) molecule located at MHC complex at chromosome 6 and chiefly attributed immunoregulatory and tolerogenic functions. HLA-G is upregulated at sites of inflammation in multiple sclerosis (MS) and assumed to counterbalance immune responses. Different functionally relevant genetic variants of HLA-G have been described and shown to...
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