Article
HLA-G genotype and HLA-G expression in systemic lupus erythematosus: HLA-G as a putative susceptibility gene in systemic lupus erythematosus.
Tissue antigens - 1 Jun 2008
Rizzo R, Hviid T V F, Govoni M, Padovan M, Rubini M, Melchiorri L, Stignani M, Carturan S, Grappa M T, Fotinidi M, Ferretti S, Voss A, Laustrup H, Junker P, Trotta F, Baricordi O R
Abstract excerpt
Systemic lupus erythematosus (SLE) is an autoimmune disease mainly mediated by the deposit of immune complexes and defects in T lymphocytes and antigen-presenting cells along with a high production of T-helper 2 cytokines. A tolerance-inducible function of nonclassical class Ib human leukocyte antigen (HLA)-G molecule in innate and adaptive cellular responses has been reported, suggesting a role in inflammatory...
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