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Article

Comparative phenotypic analysis of CHO clones and culture media for lactate shift.

Journal of biotechnology - 10 Oct 2018

Hong Jong Kwang, Nargund Shilpa, Lakshmanan Meiyappan, Kyriakopoulos Sarantos, Kim Do Yun, Ang Kok Siong, Leong Dawn, Yang Yuansheng, Lee Dong-Yup

Abstract excerpt

We explored the effects of media and clonal variation on the lactate shift which can be considered as one of the desirable features in CHO cell culture. Various culture profiles with the specific growth and antibody production rates under three different media conditions in two CHO producing clones were evaluated by resorting to multivariate statistical analysis. In most cases, glutamine depletion coincided with...

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PMID: 30076878
DOI: 10.1016/j.jbiotec.2018.07.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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