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A multi‐pronged investigation into the effect of glucose starvation and culture duration on fed‐batch CHO cell culture

20 Apr 2015

Abstract excerpt

In this study, omics-based analysis tools were used to explore the effect of glucose starvation and culture duration on monoclonal antibody (mAb) production in fed-batch CHO cell culture to gain better insight into how these parameters can be controlled to ensure optimal mAb productivity and quality. Titer and N-glycosylation of mAbs, as well as proteomic signature and metabolic status of the production cells in...

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PMID: 25899530
DOI: 10.1002/bit.25620

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